GastroPlus™ is an advanced software program that simulates the absorption, pharmacokinetics, and pharmacodynamics for drugs administered via intravenous, oral, ocular, and pulmonary routes in human and preclinical species. The underlying model is the Advanced Compartmental Absorption and Transit (ACAT) model. Since 1997, Simulations Plus has evolved the ACAT model to a high state of refinement, providing the industry’s most accurate, flexible, and powerful simulation program. This smoothly integrated platform combines a user-friendly interface with sophisticated science to help you make better project decisions... faster!

 

GastroPlus Saves Time

As pharmaceutical and biotech companies strive to reduce the enormous costs and time required to bring new drugs to market, computer tools have become an important and necessary part of drug discovery and development. From simple spreadsheets to sophisticated supercomputer molecular dynamics models, the ability of researchers to experiment in silico has become an important complement to in vitro and in vivo experimentation. GastroPlus now expands state-of-the-art computer simulation into the realm of absorption, pharmacokinetics, and pharmacodynamics.

 

Benefits of GastroPlus

• Rapid analysis and understanding of the behavior of drug candidates in animals and human.
• Understand food effects.
• Assess effects of influx and efflux transporters in gut
• Predict first-in-human/animal doses through PBPK simulation.

• Conduct virtual clinical trials.
• Fit complex nonlinear metabolism and transport in any tissue.
• Generate predictions of biopharmaceutical properties from chemical structure.
• Build PB-PK/PD models with target tissue concentrations

• Track multiple metabolites (and metabolites of metabolites)
• Deconvolute in vivo dissolution for controlled release products

GastroPlus is used by more pharmaceutical researchers than any other physiological simulation software package. This includes 18 of the top 20 pharmaceutical companies in the world. You, too, can benefit from the industry's most powerful analytical capability for absorption/pharmacokinetic/pharmacodynamics (combined with world-class support), at a fraction of the cost to develop and maintain an equivalent capability in-house.