What is the DDI Module?

The DDI Module in GastroPlus allows you to predict drug-drug interactions (DDIs) among drugs and metabolites. The ability to accurately estimate potential DDIs in silico has several benefits for pharmaceutical companies:

• Explore possible effects on the pharmacology and toxicology of drugs

• Identify species-specific changes to estimate how a drug behaves in animals vs. humans

• Investigate the safety profile of drugs that are co-administered prior to filing regulatory submissions with the FDA

With the DDI Module, calculating either steady-state and/or dynamic DDIs is managed through our easy-to-use interface. We provide a database of standard compounds for which all relevant parameters (including reported Kis and full compartmental PK/PBPK models) are defined. Of course, you may predict DDIs among any drugs by simply entering the required inputs. As with other GastroPlus modules, there is no equation or code writing required.

What are some of the advantages to using the DDI Module?

• Linked with the industry's most advanced dissolution/absorption (ACAT) model

• Use with either compartmental or physiologically based pharmacokinetics (PBPKPlus)

• Apply competitive and/or time-dependent inhibition kinetics by parent and/or metabolite(s)

• Simulate DDIs for any species (human, beagle, rat, mouse, monkey, rabbit, or cat)

• Account for enzyme expression level differences in various populations (Caucasian and Japanese)

• Built-in tool to calculate the fraction metabolized (f_m) from in vitro assays (rCYPs and microsomes are accommodated)

• Incorporate nonlinear gut contributions to DDIs

• Predict the inhibitor effect using simulated concentrations at the site of metabolism (gut, liver, or any PBPK tissue) for dynamic DDI simulations

• Include the effects of multiple substrates on clearance of other substrates metabolized by the same enzyme
  

For further information about licensing the DDI Module, please contact:

Mr. John DiBella
Director, Marketing & Sales
661-723-7723 ext. 244
john.dibella@simulations-plus.com