What is the PBPKPlus™ Module?
Ranked as the #1 PBPK software for In Vitro-In Vivo Extrapolation (IVIVE) & PBPK modeling by Pfizer!
(Cole et al., 2nd Asian Pacific Regional ISSX Meeting, May 2008, Shanghai, China)
NEW! Improved handling of covariates in Population Simulator.
NEW! Additional disease physiology groups (obesity, renal impairment)
NEW! Clearance mechanisms in blood compartments
Upgraded! Infant PBPK models – easily perform pediatric PBPK modeling to capture the pharmacokinetics and pharmacodynamics in infants as young as 16 weeks premature, with automatic scaling of physiological parameters (e.g., hematocrit, plasma protein levels) with age!
Want to see the PBPKPlus Module in action? Take a look at some recent posters focused on pediatric PBPK simulations. More applications can be seen while visiting the DDI Module page or our Resource Center.
Prediction of Acyclovir Pharmacokinetics in Pediatric Populations using a Physiologically Based Pharmocokinetic (PBPK) ModelLearn More
Lukacova, V., M.B. Bolger, W.S. Woltosz
Prediction of Valsartan Pharmacokinetics in Pediatric Population using Physiologically Based Pharmacokinetic (PBPK) ModelLearn More
Lukacova, V., M.B. Bolger, W.5. Woltosz
Physiologically based pharmacokinetic (PBPK) model for prediction of vancomycin pharmacokinetics in childrenLearn More
Lukacova, V. , W.S. Woltosz,
The influence of dissolution, PMAT influx, and MATE efflux rates on paracellular absorption of metformin using a mechanistic oral absorption / PBPK modelLearn More
Michael B. Bolger, Joyce Macwan and Viera Lukacova