PBBM PBPK Modeling Scientist

Simulations Plus, Inc. (Nasdaq: SLP) is a leading provider of modeling and simulation software and consulting services supporting drug discovery, development research, and regulatory submissions. With our subsidiaries, Cognigen, DILIsym Services, and Lixoft, we offer solutions that bridge machine learning, physiologically based pharmacokinetics, quantitative systems pharmacology/toxicology, and population PK/PD modeling approaches. Our technology is licensed and applied by major pharmaceutical, biotechnology, chemical, consumer goods companies, and regulatory agencies worldwide. 

The Simulation Sciences team is looking for a Scientist II, Senior Scientist I, or Senior Scientist II (dependent on experience and qualifications.)


  • Drive the development and testing of software products such as GastroPlus®, MembranePlus­™, and DDDPlus™
  • Perform PBBM/PBPK modeling and simulation to address objectives with client projects, including, but not limited to, FIH predictions, formulation design/optimization, population simulations, special populations, disease state modeling, and DDI predictions
  • Write study proposals, modeling reports, white papers, and/or journal publications to clearly describe model development and verification
  • Discuss software applications with clients and prospects on the telephone or in-person
  • Attend and/or present at scientific conferences
  • Perform other related duties as assigned

This position reports to either the Director – Simulation Technologies or the Executive Director – Simulation Studies.


  • M.S. or Ph.D. (or equivalent) in Pharmaceutical Science, Biostatistics, Biomedical Engineering, or related fields


  • Knowledge of PBBM PBPK modeling applications in preclinical development and/or clinical pharmacology
  • Prior experience of working in the pharmaceutical industry or postdoctoral research related to PBPK modeling preferred
  • Experience in using GastroPlus, and Simulations Plus software products such as ADMET Predictor, MembranePlus and DDDPlus, or other commercial PBPK packages is desired
  • Excellent oral and written communication skills
  • Demonstrate and communicate a positive attitude while interacting with colleagues and clients at all levels
  • Build and maintain strategic partnerships across industry
  • Must be able to multitask and have strong organizational skills
  • Self-motivated with the ability to work with minimal supervision
  • Some travel required (<10%)

Job Location:

  • Lancaster, CA, though remote options will definitely be considered


  • Competitive base salary and merit-based bonus