Immediate openings for Scientist II, Senior Scientist and Senior Scientist II in our Simulation Technologies team to develop and apply software tools in the following areas:

• simulation and prediction of compound distribution in humans and animals
• simulation and prediction of in vitro dissolution experiments and IVIVC
• simulation and prediction of compounds’ behavior in in vitro cell culture assays

 The responsibilities include:

• Conducting literature searches for data and methods related to the assigned scientific area (in vitro and in vivo measurements of compound interactions with cell or tissue components, and/or in vitro dissolution experiments and formulation design).
• Constructing and validating relevant mechanistic mathematical models (e.g., physiology-based descriptions of compound distribution in different regions of the body, descriptions of compound- and formulation-dependent dissolution, and descriptions of compound interactions with tissue samples and isolated cells).
• Constructing and validating models for translation of in vitro data into meaningful in vivopredictions based on underlying processes occurring in both systems.
• Discuss software application issues with clients and others on telephone, email, Internet meetings, and/or in person.
• Travel to professional conferences as an attendee and/or an exhibitor.
• Make formal presentations at professional conferences.
• Visit customer sites to provide training and consultation.

Requirements:

M.S. or Ph.D. degree or equivalent in Biochemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Science, or related discipline

At least one year experience as Scientist, Research Associate, or related

Demonstrated at least one year full-time programming experience in C++ or VB

Demonstrated modeling experience in one or more of the following areas:

• physiologically based modeling of compound distribution in human and/or animals
• in vitrodissolution, formulation design and IVIVC
• in vitrocell culture assays, evaluation of compound metabolism or interactions with transporters

Excellent English written and oral communication skillsExcellent problem-solving skills, ability to quickly learn new technologies and scientific principles in the above-outlined areas of interest.

Ability to multitask and meet assigned deadlines

Location:

Los Angeles Area (Position in Lancaster, CA)

Salary/Benefits:

DOE. Competitive pay and generous benefits package with a highly successful and financially stable public company founded in 1996.