Senior Scientist Position

Job Duties

Analyze and interpret preclinical and clinical data. Study the effect of diseases on animal and/or human physiology. Conduct research to further understanding of the effect of healthy and disease states on drug absorption, distribution, and elimination.

Use mechanistic modeling and simulation approaches to integrate knowledge of pharmacokinetics, pharmacodynamics, efficacy, safety, patient demographics, and pathophysiological factors.

Perform mechanistic PBPK modeling and simulation to establish dose-exposure-response relationship for studied drugs.

Predict human pharmacokinetics and first-in-human dose based on in vitro and animal data.

Explore and design the optimal drug formulation/release profile to fulfill safety and efficacy requirements.

Write study proposals and study reports.

Prepare case studies based on published data for marketed drugs demonstrating utility and applicability of the Company software. Contribute to the development process of the Company software.

Conduct literature searches for data and methods related to in vitro and in vivo measurements of compound interactions with tissue components.

Construct and validate mechanistic mathematical models for description of compound distribution in different tissues/organs in the body.

Discuss software applications with clients and prospects on telephone or in person. Travel to professional conferences as an attendee and/or an exhibitor.

Share research findings by writing scientific articles and/or present at scientific conferences.



Ph.D. Degree or equivalent in Pharmaceutical Science, Biostatistics, Biomedical Engineering, or related fields.


Two years of experience as Scientist, Research Associate, or related.

Experience should include performing physiologically-based modeling of distribution of compounds in animals and humans.  It should also include performing PBPK/PD analyses of clinical data, including drug absorption, drug-drug interaction, metabolic stability, clearance, and protein binding.

The required experience may have been gained prior to or concurrently with the required education.

Any suitable combination of education, training or experience is acceptable.

Travel required (10-20%).


Los Angeles Area (Position in Lancaster, CA)


DOE. Competitive pay and generous benefits package with a highly successful and financially stable public company founded in 1996.