Sr. PBPK Modeler

Simulations Plus is a leading developer of modeling and simulation software, and a provider of consulting services. We support our pharmaceutical and biotechnology clients through drug discovery, development research, and regulatory submissions.

Leadership truly cares about maintaining a positive culture and for employee well-being. We offer fully remote work, flexible schedules, unlimited vacation along with free medical premiums, stock options, bonus potential, and more!

The Sr. PBPK Modeler will perform PBBM/PBPK modeling and simulation to address objectives with client projects such as FIH predictions, formulation design/optimization, population simulations, and DDI predictions.

Division: Simulations

Department: Life Sciences

Location: This position can be 100% remote or hybrid near Lancaster, CA

 Job Responsibilities:

  • Support research collaboration projects with industry partners and regulatory agencies
  • Review, compile, and document data from various sources
  • Build and validate PBBM/PBPK models
  • Contribute to the advancement of scientific algorithms and approaches
  • Serve as technical lead on PBBM/PBPK modeling and simulation client projects
  • Write study proposals, modeling reports, white papers, and journal publications while clearly describing model development and validation
  • Mentor and supervisor junior scientist to better support model development and client needs
  • Discuss software applications with potential and current clients
  • Assist in the testing of software products
  • Help in the preparation of training materials
  • Attend and present at scientific conferences
  • Other duties as assigned 


  • Expert knowledge of PBBM/PBPK modeling applications from preclinical development to clinical pharmacology
  • Excellent verbal and written communication skills
  • Fluent in multiple languages a plus
  • Maintain a positive attitude while interacting with colleagues and clients
  • Build and strengthen strategic partnerships across the industry
  • Must be able to multitask and have strong organizational skills
  • Self-motivated with ability to work with minimal supervision
  • Minimal travel required up to 10% 


  • Masters in pharmaceutical science, biostatistics, biomedical engineering, chemistry, or related field
  • PhD in pharmaceutical science, biostatistics, biomedical engineering, chemistry, or related field preferred

Find out more about how amazing it is to work at Simulations Plus by visiting and apply today!

Base Pay Range: 125k – 150k USD per year