CANCELED: SOT 59th Annual Meeting & ToxExpo

SOT 59th Annual Meeting & ToxExpo

March 15-19

Anaheim, California

Booth number 760

Attendees: Scott Siler, John DiBella, Michael Lawless, Jim Mullin, Eric Jamois, Arlene Padron, Vinal Lakhani, and Yeshi Gebremichael

Lunch & Learn: Next Generation of Simulations Plus Software Tools Enable Accurate Exposure and Safety Assessments

Time: 12:00 PM – 1:00 PM Mon. Mar. 16 CC Room 205B

State-of-the-art modeling and simulation software tools will be discussed, including the latest updates to the most widely used absorption, formulation, and PBPK platform, GastroPlus, as well as updates on the QST safety platforms DILIsym (liver injury) and RENAsym (kidney injury). Application examples will be shared.

John DiBella to present “Mechanistic ML/PBK Modeling to Support Next Generation Risk Assessment”

Scott Siler to present “Modeling DILI Drug-Drug Interactions with DILIsym”

Poster Title: 1242: Poster Board – P304 Mechanistic Modeling Aids in the Interpretation of Alanine Aminotransferase Elevations Associated with Clinical Idiosyncratic Drug-Induced Liver Injury

Presenter: Rachel Church, University of North Carolina Institute for Drug Safety Sciences, Research Triangle Park, NC

Session: Biomarkers, CC Exhibit Hall, 10:45 – 12:30 PM AM Mon. Mar. 16

Poster Title: 2032: Poster Board – P36 Using In Silico-In Vitro to In Vivo Extrapolation to Predict the Oral Dose Required to Activate the Aryl Hydrocarbon Receptor (AhR)

Presenter: Michael Lawless

Session: Computational Toxicology I, CC Exhibit Hall, 9:00 AM – 10:45 AM Tues. Mar. 17

Poster Title: 2942: Poster Board – P572 Generalized PBPK Model for Evaluation of Inhalation Exposure of Volatile Organic Compounds

Presenter: Jim Mullin

Session: Biological Modeling, CC Exhibit Hall, 9:00 AM – 10:45 AM Wed. Mar. 18

Poster Title: 2964: Poster Board – P595 Quantitative Systems Toxicology (QST) Reproduces Species Differences in PF-04895162 Liver Safety Due to Combined Mitochondrial and Bile Acid Toxicity

Presenter: Vinal Lakhani

Session: Computational Toxicology II, CC Exhibit Hall, 2:15 PM – 4:30 PM Wed. Mar. 18

Poster Title: 2969: Poster Board – P600 Quantitative Systems Toxicology Modeling of Cisplatin Nephrotoxicity Using In Vitro Assays of Proximal Tubule Epithelial Cells for Mechanistic Toxicity Pathways

Presenter: Yeshi Gebremichael

Session: Computational Toxicology II, CC Exhibit Hall, 2:15 PM – 4:30 PM Wed. Mar. 18