Advanced training is broken into two expert courses to get the most out of GastroPlus® at a practical level. A case study from a US pharmaceutical company is conducted as a case study. This is especially recommended for those who have participated in the above GastroPlus® Introductory Workshop. Learn how to use modeling and simulation for complex phenomena that affect each other such as absorption, PBPK / PD, DDI, administration route, and dosage form. Understand drug absorption (passive transport / carrier transport), metabolism and distribution processes in the small intestine and other tissues, pharmacokinetics (compartments PK, PBPK), and mechanistic interactions that affect pharmacodynamics. You will learn how to properly use modeling and simulation in formulation evaluation and formulation design that examines dissolution, absorption, pharmacokinetics, administration route, and dosage form. Understand the mechanistic interactions affecting small intestinal transit, absorption (passive transport / carrier transport), first pass metabolism and PK and the effects of these phenomena on the drug product.
The Introductory Workshop is a hands-on, practical three-day training course that provides deep learning of the basic theory and application of GastroPlus ® . The objective is to acquire the basic theory, modeling and simulation required for GastroPlus® . Because it is a beginner course, deep knowledge and experience of GastroPlus ® are not required. In Introductory Workshop , you will learn the following: Understand the interactions that exist in various mechanistic phenomena affecting drug absorption, pharmacokinetics (compartments PK, PBPK), and pharmacodynamics. Predict drug properties from chemical structure using ADMET Predictor ™ module, Evaluation of PBPK model and compartment model, Prediction of human first-dose study dose from preclinical and in vitro data, Evaluation of formulation strategies such as micronization and nano-fabrication, Fitting nonlinear metabolic and transport models, Tracking parent and metabolite concentrations in plasma and tissues, Optimization method, objective function weighting, binding conditions, Construction of PBPK / PD model, Population simulation, IVIVC analysis, Metabolic and transporter-based drug-drug interactions, Biologic PBPK modeling
GastroPlus ™ Workshop is a hands-on intensive training course instructed by a scientist from Simulations Plus, a developer of pharmacokinetic analysis / formulation design support software GastroPlus ™. This workshop has the same content and is held every year in the United States, Europe and other countries. In addition to deeply learning the basic theory and application of GastroPlus ™ , it is structured so that you can acquire modeling and simulation in this field. As before, we have participated as a lecturer by three scienceists from Simulations Plus, GastroPlus ™ Introductory Workshop which is a three day introductory course and GastroPlus ™ Advanced Training Workshop which is a two day advanced course training course, We will hold it at the Tokyo / Shinagawa Season Terrace Conference on a schedule.
This 2-day hands-on course will provide an in-depth knowledge of the theories and application of state-of-the-art simulation and modeling software as it applies to problems facing DMPK and Clinical Pharmacology scientists dealing with complex effects on drug absorption, pharmacokinetics, pharmacodynamics, and drug-drug interactions. A combination of presentations and interactive examples, taken from actual industry experience, will illustrate how to recognize and deal with the multiple interacting phenomena that affect the absorption, PBPK/PD, and DDIs of particular drugs, dosing routes, and dosage forms in different populations.
This 2-day hands-on course will provide an in-depth knowledge of the theories and application of state-of-the-art simulation and modeling software as it applies to problems facing pharmaceutical scientists dealing with drug product effects on dissolution, absorption and pharmacokinetics. Focus will be placed on applications of this technology as it relates to issues defined in the FDA’s Critical Path Initiative. A combination of presentations and examples, taken from actual industry experience, will illustrate how to recognize and deal with the multiple interacting phenomena that affect the dissolution, absorption and pharmacokinetics of particular drugs, dosing routes and dosage forms.
This three-day, hands-on course provides a working knowledge of the basic theories and application of state-of-the-art PBPK simulation and modeling software for the analysis of drug dissolution and absorption, coupled with the resulting pharmacokinetics and pharmacodynamics. A combination of presentations and interactive examples, taken from actual industry experience and using GastroPlus, illustrate how to recognize and deal with the multiple interacting phenomena that affect the absorption, PBPK/PD and DDIs of particular drugs and dosage forms.