Drug-induced kidney injury remains a significant concern in pharmaceutical development, with traditional methods often falling short in predicting renal toxicity across diverse compounds and patient populations. RENAsym is a quantitative systems toxicology (QST) platform used for mechanistic modeling of kidney injury, allowing researchers to predict, understand, and manage kidney safety concerns.

Learn about the latest enhancements, including:

• New biological components: Discover the addition of podocyte and distal tubule models—key for simulating glomerular and tubular injury mechanisms.
• Improved crystal nephropathy modeling: Explore enhancements that provide more accurate simulation of crystal-associated renal damage.
• Novel biomarkers: Learn how new biomarker representations support early detection and mechanistic insight
• Real-world applications: Review novel predictions for compounds like lithium and polymyxin B, showcasing the power of QST in action.

Speaker: Jeff Woodhead