This tutorial for MedChem Studio™ (within ADMET Predictor®) focuses on the practical application of clustering and chemotype analysis using a natural product mimetic dataset. Key techniques covered include using ring-anchored systems to generate classes, analyzing property distributions across clusters with graphical histograms, and aligning common scaffolds using MedChem Designer™. The video also details how to use the R-table analyzer to explore substitution patterns and how to “explode” a core scaffold into a full virtual library for further screening.