This advanced tutorial for ADMET Predictor focuses on identifying the underlying drivers of drug absorption. Learn to use the PSA tool to run multiple simulations that vary solubility and permeability independently, revealing critical “rescue” strategies for solubility-limited compounds. The second half of the video provides a practical workflow for importing experimental solubility data, showing how the software seamlessly uses available lab results while reverting to internal models for missing data points. This hybrid approach allows researchers to leverage high-throughput experimental values to refine their pharmacokinetic simulations.