State-of-the-Art on Tissue Partitioning and Volume of Distribution Predictions

Authors: Lukacova V
Conference: ISSX
Keywords: fih, gastroplus, ISSX 2026, MIDD, PBPK modeling
Summary
  • Mechanistic (semi-mechanistic) methods are available to predict tissue partitioning (Kp) and Vss from compound properties and tissue physiology.
  • Prediction accuracy depends on reliable inputs and method assumptions that match the compound’s distribution mechanisms.
  • When predictions miss observed Vss, investigate input uncertainty and missing mechanisms before making empirical adjustments.
  • Sensitivity analysis can be used to evaluate which inputs drive Kp and Vss uncertainty for each compound.

By Viera Lukacova

ISSX – 27th North American Meeting, October 11-14, 2026, San Francisco, California