“Physiologically Based Pharmacokinetic (PBPK) Modeling“ workshop is hosted by the GMP and co-organized by the directors of the Master 2 in PK (Lyon, Marseille, Paris, and Toulouse), ESQlabs, Simulations Plus, and the GMP. It will be held from 24th to 26th November 2026 at the Lyon Faculty of Pharmacy (France).

This workshop is designed to provide participants with the knowledge and skills required for Physiologically Based Pharmacokinetic (PBPK) modeling. New Chemical and Biological Entities will be considered when applicable.

The number of participants is limited to 35

Agenda:

1 day: four keynote lectures (90 to 120 minutes each) on the main applications of PBPK (including case studies)

2 days: hands-on exercises with keynote lectures on biologics. GastroPlus hands-on program:

• Practical Guide to Define API Distribution Using PBPK Models
• Clearance IVIVE Using PBPK Models
• Practical PBPK Considerations for Oral Models
• PBPK Model application: Drug-Drug Interactions PK
• Sim hands-on program on biologics
• Develop PBPK models for an ADC: one for the large molecule, and one for the small molecule payload.
• Modularization 1: Add a Target-Mediated Drug Disposition reaction network as a reaction extension module.
• Modularization 2: Add a tumor organ as a physiological extension module.
• Work with separate modules to demonstrate how modular workflows streamline model management, reuse, and extension.

GastroPlus Instructors: Fiona Plait and Maxime Le Merdy