• Software
    • GastroPlus®
    • MonolixSuite™
    • ADMET Predictor®
    • DILIsym®
    • DDDPlus™
    • NAFLDsym®
    • MembranePlus™
    • PKanalix™
    • Simulx™
    • IPFsym®
    • ILDsym™
    • RENAsym®
    • MedChem Designer™
    • Custom QSP Software
  • Services
    • Overview
    • Pharmaceutical
      • PBPK Modeling and Simulation
      • Pharmacometric Data Assembly
      • Training and Workshops
      • Learning Services
      • Resident Clinical Pharmacology Services
      • Noncompartmental PK/TK Analysis
      • Early Drug Discovery
      • Model-Driven Development Strategies
      • PopPK & Exposure Response Modeling
      • PK/PD Support
      • Liver Safety Modeling and Analysis
      • QSP Modeling of NAFLD & NASH
      • Custom QSP Services
    • Chemical, Cosmetics, and Food Industries
      • Early Drug Discovery
      • PBTK Modeling and Simulation
    • Global Regulatory Strategies
    • Concierge Program
    • Consult + Coach
  • Careers
    • Openings
    • Apply Online
  • Resource Center
  • Events
    • Upcoming Events
    • Scientific Meetings
    • Webinars
    • Workshops
    • Past Events
    • On Demand
  • Investors
    • Conference Calls & Presentations
    • Environmental, Social and Governance (ESG)
    • Corporate Profile
    • Board of Directors
    • SEC Filings
    • Press Releases
    • Shareholder Information
  • About
    • Contact
    • Our Team
    • Simulations Plus
      • Simulations Plus Team
      • Simulations Plus Scientific Advisory Board
    • DILIsym® Services
      • DSSI Team
      • DILI-sim Initiative
        • DILIsym Scientific Advisory Board
        • DILIsym Development
      • RENAsym Consortium
        • RENAsym Scientific Advisory Board
    • Cognigen® Services
      • Cognigen Team
    • Lixoft™
      • Lixoft Team
    • SLP University+ Program
      • Learning Services
      • Internship+
    • Leadership
    • Partners and Collaborators
    • Privacy Policy
  • Portal Login
  • Search
Simulations Plus logo
Simulations Plus logo

Simulations Plus

We Improve Health Through Innovative Solutions

  • Software
    • GastroPlus®
      • GastroPlus®
        GastroPlus®
        PBBM/PBPK
        View Product

        PBBM / PBPK modeling & simulation software package which simulates all major dosing routes and drug-drug interactions (DDIs) in virtual human & animal population groups.

        Request Software Evaluation
      • Modules

        • Drug Drug Interaction
        • PBPKPlus™
        • ADMET Predictor®
        • Additional Dosage Routes
        • Metabolism & Transporter
        • Biologics
        • Optimization
        • PDPlus™
        • PKPlus™
        • IVIVCPlus™
        • Plug n’ Play
      • More Info

        • Peer-reviewed publications citing applications of GastroPlus
        • Software Introduction
        • GastroPlus Tutorials
      • Shortcuts

        • Workshops
        • Simulations Plus Releases GastroPlus® Version 9.8.3
        • GastroPlus 9.8.3 Flyer
        • GastroPlus® Additional Dosage Routes Brochure
    • MonolixSuite™
      • MonolixSuite™
        MonolixSuite™
        PK/PD
        View Product

        Easy, fast, and powerful tool for parameter estimation in non-linear mixed effect models, model diagnosis and assessment, and advanced graphical representation.

        Request Software Evaluation
      • Suite

        • Monolix™
        • PKanalix™
        • Simulx™
      • More Info

        • Monolix Documentation
        • PKanalix Documentation
        • Simulx Documentation
        • Mlxtran Documentation and Language Reference
        • Data Set Documentation
      • Shortcuts

        • MonolixSuite™ 2023 Flyer
        • Watch MonolixSuite™ R2023 Webinar
    • ADMET Predictor®
      • ADMET Predictor®
        ADMET Predictor®
        ADMET/ML
        View Product

        Flagship machine learning platform for ADMET modeling with extended capabilities for data analysis, metabolism prediction, high-throughput pharmacokinetic simulation (HTPK), and AI-driven drug design.

        Request Software Evaluation
      • Modules

        • Overview
        • AI-Driven Drug Design (AIDD)
        • Metabolism
        • Transporters
        • Toxicity
        • Physicochemical & Biopharmaceutical
        • ADMET Modeler™
        • High-throughput Pharmacokinetic (HTPK) Simulation
        • MedChem Studio™
      • More Info

        • ADMET Predictor® REST API
        • Download the APX.4 Flyer
        • Peer-reviewed publications citing applications of ADMET Predictor
        • ADMET Predictor Tutorials
      • Shortcuts

        • ADMET Predictor® 10.4 (APX.4) Release Webinar
        • ADMET Predictor® Tutorial
    • DILIsym®
      • DILIsym®
        DILIsym
        QST
        View Product

        Quantitative Systems Toxicology (QST) software designed to be used during drug development to provide deeper insight into the mechanisms responsible for observed drug-induced liver injury (DILI) responses.

        Request Software Evaluation
      • Submodels

        • Overview
        • SimPops®
        • PBPK Modeling
        • Mitochondrial Function
        • Bile Acid Modeling
        • Reactive Nitrogen/Oxygen Species
        • Innate Immunity modeling
        • Hepatocyte Life Cycle
        • Clinical Readouts
      • More Info

        • Applications and Regulatory Impact
        • DILIsym Inputs from Cyprotex
        • DILIsym Inputs from SOLVO
        • Corporate Licenses
        • Academic Licenses
        • FAQs
      • Shortcut

        • DILIsym® Product Brochure
        • Membership Login
    • DDDPlus™
      • DDDPlus™
        DDDPlus™
        PBBM/PBPK
        View Product

        A mechanistic simulation engine for the in vitro dissolution experiment that predicts in vitro disintegration and dissolution of pharmaceutical dosage forms.

        Request Software Evaluation
      • Modules

        • Overview
        • ADMET Predictor®
      • Shortcuts

        • DDDPlus Product Brochure
        • Simulations Plus Releases DDDPlus™ Version 6
        • DDDPlus™ 6 Webinar
    • NAFLDsym®
      • NAFLDsym®
        NAFLDsym®
        QSP
        View Product

        Quantitative Systems Pharmacology (QSP) software for mechanistic mathematical modeling of nonalcoholic fatty liver disease (NAFLD.)

        Request Software Evaluation
      • More Info

        • Overview
      • Shortcuts

        • NAFLDsym® Product Brochure
        • QSP/QST Capabilities Flyer
        • NAFLDsym® 2B Press Release
        • Workshops
        • NAFLDsym® Video: Prediction of Clinical Response to ACC Inhibition
        • NAFLDsym® Video: Prediction of Clinical Response to Hepatic AMPK Activation
        • NAFLDsym v2A Release Webinar
    • MembranePlus™
      • MembranePlus™
        MembranePlus™
        PBBM/PBPK
        View Product

        A detailed modeling & simulation program for in vitro metabolism & transport studies.

        Request Software Evaluation
      • Modules

        • Overview
        • Optimization
        • ADMET Predictor®
      • Shortcuts

        • Simulations Plus Releases MembranePlus™ 3.0
        • MembranePlus v3 Product Brochure
        • MembranePlus™ Version 3.0 Release Notes
    • PKanalix™
      • PKanalix™
        PKanalix™
        PK/PD
        View Product

        Graphical and interactive software for non-compartmental and compartmental analysis.

        Request Software Evaluation
      • More Info

        • Overview
      • Shortcuts

        • Watch MonolixSuite™ R2023 Webinar
        • Documentation website
    • Simulx™
      • Simulx™
        Simulx™
        PK/PD
        View Product

        A powerful and flexible simulator for clinical trial pharmacometrics.

        Request Software Evaluation
      • More Info

        • Overview
      • Shortcuts

        • Watch MonolixSuite™ R2023 Webinar
        • Documentation website
    • IPFsym®
      • IPFsym®
        IPFsym®
        QSP
        View Product
        IPFsym®

        Quantitative Systems Pharmacology (QSP) software providing the ability to predict the efficacy of drugs being developed to treat idiopathic pulmonary fibrosis (IPF.)

        Request Software Evaluation
      • More Info

        • Overview
      • Shortcuts

        • Cust QSP/QST Services Flyer
        • IPFsym® version 1A Press Release
        • Workshops
        • IPFsym™ Product Brochure
    • ILDsym™
      • ILDsym™
        ILDsym™
        QSP
        View Product
        ILDsym™

        Quantitative Systems Pharmacology (QSP) software for mechanistic mathematical modeling of interstitial lung disease (ILD) associated with system sclerosis (SSc.)

        Request More Information
      • More Info

        • Overview
      • Shortcuts

        • Custom QSP/QST Services Flyer
        • View QSP/QST Workshops
        • MIDD 2022 Replays
    • RENAsym®
      • RENAsym®
        RENAsym®
        QST
        View Product
        RENAsym®

        Quantitative Systems Toxicology (QST) software for predicting and understanding drug-induced kidney injury.

        Request Software Evaluation
      • More Info

        • Overview
      • Shortcut

        • RENAsym® Version 1A Press Release
        • RENAsym, a QST Model to Predict Drug-Induced Kidney Injury
        • QSP/QST Capabilities Flyer
    • MedChem Designer™
      • MedChem Designer™
        MedChem Designer™
        ADMET/ML
        View Product
        MedChem Designer™

        FREE chemical sketching software tool which combines innovative molecule drawing features.

        Download MedChem Designer
      • More Info

        • Overview
        • Download for Free
        • Free 30-Day Evaluation of ADMET Predictor®
      • Shortcuts

        • MedChem Designer Product Brochure
        • MedChem Designer 3.0 Press Release
        • ADMET Predictor Tutorial 2: MedChem Designer
    • Custom QSP Software
      • Custom QSP tools for your application
        View Product

        Custom QSP software for predicting efficacy & guiding design.

        Contact Us
      • More Info

        • Overview
      • Shortcuts

        • Custom QSP/QST Service Flyer
        • RENAsym®
        • Custom QSP: IPFsym®
        • Custom QSP: NAFLDsym®
  • Services
    • Overview
    • Pharmaceutical
      • PBPK Modeling and Simulation
      • Pharmacometric Data Assembly
      • Training and Workshops
      • Learning Services
      • Resident Clinical Pharmacology Services
      • Noncompartmental PK/TK Analysis
      • Early Drug Discovery
      • Model-Driven Development Strategies
      • PopPK & Exposure Response Modeling
      • PK/PD Support
      • Liver Safety Modeling and Analysis
      • QSP Modeling of NAFLD & NASH
      • Custom QSP Services
    • Chemical, Cosmetics, and Food Industries
      • Early Drug Discovery
      • PBTK Modeling and Simulation
    • Global Regulatory Strategies
    • Concierge Program
    • Consult + Coach
  • Careers
    • Openings
    • Apply Online
  • Resource Center
      • 2023 MIDD+ Replays
      • Blog
      • Contact Support
      • Datasheets
      • Flyers
      • Journal Articles
      • PKPlus User Group
      • Posters
      • Presentations
      • Press Releases
      • Product Brochures
      • Software Installation
      • The Simulations Plus Customer Portal
      • Videos
      • Webinars
      • White Papers
    • Featured Webinar Replay

  • Events
    • Upcoming Events
    • Scientific Meetings
    • Webinars
    • Workshops
    • Past Events
    • On Demand
  • Investors
    • Conference Calls & Presentations
    • Environmental, Social and Governance (ESG)
    • Corporate Profile
    • Board of Directors
    • SEC Filings
    • Press Releases
    • Shareholder Information
  • About
    • Contact
    • Our Team
    • Simulations Plus
      • Simulations Plus Team
      • Simulations Plus Scientific Advisory Board
    • DILIsym® Services
      • DSSI Team
      • DILI-sim Initiative
        • DILIsym Scientific Advisory Board
        • DILIsym Development
      • RENAsym Consortium
        • RENAsym Scientific Advisory Board
    • Cognigen® Services
      • Cognigen Team
    • Lixoft™
      • Lixoft Team
    • SLP University+ Program
      • Learning Services
      • Internship+
    • Leadership
    • Partners and Collaborators
    • Privacy Policy
Resource Center
Neoadjuvant

Searching through 26000+ documents...

Latest Journal Articles
Acalabrutinib Maleate Tablets: The Physiologically Based Biopharmaceutics Model behind the Drug Product Dissolution Specification
  • March 1, 2023
  • Journal Articles
Acalabrutinib Maleate Tablets: The Physiologically Based Biopharmaceutics Model behind the…
Pepin X, McAlpine V, Moir A, Mann J
  • Read More
  • Click to View
Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies and Evaluation Approaches
  • February 27, 2023
  • Journal Articles
Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies…
Gan Y, Baak JPA, Chen T, Ye H, Liao W, Lv H, Wen C, Zheng S
  • Read More
  • Click to View
Mechanistic Modeling of Ophthalmic, Nasal, Injectable, and Implant Generic Drug Products: A Workshop Summary Report
  • February 27, 2023
  • Journal Articles
Mechanistic Modeling of Ophthalmic, Nasal, Injectable, and Implant Generic Drug…
Tan ML, Chandran S, Jereb R, Alam K, Bies R, Kozak D, Walenga R, Le Merdy M, Babiskin A
  • Read More
  • Click to View
Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium “Long-Acting Injectables” Working Group
  • February 22, 2023
  • Journal Articles
Current State and Opportunities with Long-acting Injectables: Industry Perspectives from…
Bauer A, Berben P, Chakravarthi SS, Chattorraj S, Garg A, Gourdon B, Heimbach T, Huang Y, Morrison C, Mundhra D, Palaparthy R, Saha P, Siemons M, Shaik NA, Shi Y, Shum S, Thakral NK, Urva S, Vargo R, Koganti VR, Barrett SE
  • Read More
  • Click to View
Assessment of food effects during clinical development
  • February 18, 2023
  • Journal Articles
Assessment of food effects during clinical development
Vinarov Z, Butler J, Kesisoglou F, Koziolek M, Augustijns P
  • Read More
  • Click to View
Ready to get started?

Sign-up for a free evaluation or schedule a meeting with one of our experts!

Questions? Email info@simulations-plus.com

Discuss my project needs with an expert
Schedule a software demo
Join our newsletter
Software
  • GastroPlus®
  • MonolixSuite™
  • ADMET Predictor®
  • DILIsym®
  • DDDPlus™
  • NAFLDsym®
  • MembranePlus™
  • PKanalix™
  • Simulx™
  • IPFsym®
  • ILDsym™
  • MITOsym®
  • MedChem Designer™
  • Custom QSP Software
Services
  • Early Drug Discovery
  • Global Regulatory Strategies
  • Liver Safety Modeling and Analysis
  • Noncompartmental PK/TK Analysis
  • PBPK Modeling and Simulation
  • PK/PD Support
  • PopPK & Exposure Response Modeling
  • QSP Modeling of NAFLD & NASH
  • Training and Workshops
Careers
  • Openings
  • Apply Online
Resource Center
  • Blog
  • Contact Support
  • Journal Articles
  • Posters
  • Product Brochures
  • Software Installation
  • Videos
  • Webinars
Investors
  • Board of Directors
  • Environmental, Social and Governance (ESG)
  • Latest Presentations
  • Press Releases
  • SEC Filings
  • Shareholder Information
About
  • Simulations Plus
  • Contact
  • Leadership
  • Partners and Collaborators
  • Privacy Policy
  • Vision, Mission & Values
  • FCOI Policy
Simulations Plus
  • GastroPlus
  • Copyright © 2023 Simulations Plus. All Rights Reserved.
    • Privacy Policy
    • Sitemap
    • Terms of Use
    • Cookie Settings
This website uses cookies
We use cookies to enhance your browsing experience and analyze our traffic. To learn more about our use of cookies and other tracking technologies, please see our Cookie Consent Policy and our Privacy Policy. By clicking “Accept All,” you consent to such use by us of cookies and other tracking technologies. If you are in the EU, UK or other country requiring consent for international transfer of personal data, by clicking “Accept All” you expressly consent to the transfer of your personal data to the US. To learn more about your privacy rights and our personal data practices, please see our Privacy Policy.
Accept All Reject AllCookie Settings
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
Save & Accept