Advancing NAMS with Quantitative Systems Toxicology and Microphysiological Systems

Authors: Woodhead JL
Conference: AAPS
Keywords: AAPS 2026, DILIsym, drug toxicity, in vitro, New Approach Methodologies (NAMs), Quantitative Systems Toxicology (QST), Toxicity predictions
Software: DILIsym®
Session Description and Objectives
  • Quantitative systems toxicology (QST) is a proven method for translating in vitro inputs to toxicity predictions
  • Biologicsandothernon-small-molecule treatment modalities present different translational challenges
  • QST can help translate novel NAM-derived data into toxicity predictions
  • Understand how QST makes predictions from in vitro data inputs
  • Understand the unique QST challenges presented by large molecules
  • Understand how large molecule NAM-based in vitro data can be used as QST inputs

By Jeff Woodhead

AAPS PharmSci 360 2026, October 25-28, 2026, New Orleans, Louisiana