Application of Modeling and Simulation in Long-Acting Injectable Product Development

Authors: Lukacova V
Conference: AAPS
Keywords: AAPS 2022, in vitro, in vivo, Long Acting Injectable, modeling and simulation, PBPK models
Software: DDDPlus™, GastroPlus®, MembranePlus™
Division: Simulations Plus

Objectives

  • Identify processes that impact the drug release from PLGA particles
  • Identify processes that impact the in vivo drug dissolution from long acting injectable crystalline suspensions
  • Define areas for further development to increase the predictability of PBPK models

By Viera Lukacova

Presented at American Association of Pharmaceutical Scientists (AAPS) Pharm Sci 360 Boston, Massachusetts October 16-19, 2022​