Application of PBPK Modeling in Pediatric Drug Development (GastroPlus®)

Authors: Lukacova V
Software: GastroPlus®
Division: Simulations Plus

Outline

Why?

  • Role of PBPK in pediatric drug development

How?

  • Pediatric physiology:
    • Tissue growth
    • Tissue and blood composition
    • Intestinal physiology
  • Clearance and dispostion scaling
    • Metabolic clearance
    • Glomerular filtration
    • Transporters

What?

  • Applications

By Viera Lukacova

Download Slides