Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review

Authors: Guimarães M, Statelova M, Holm R, Reppas C, Symilllides M, Vertzoni M, Fotaki N
Publication: J Pharm Pharmacol
Keywords: dose selection, formulation design, mechanistic absorption modeling, PBPK model, pediatrics
Software: GastroPlus®

Objectives

In this review, the current biopharmaceutical approaches for evaluation of oral formulation performance in paediatrics are discussed.