• Contact Us
    •

    Resource Center

    Jul 3, 2018
      |  Journal Article

    Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review

    Guimarães M, Statelova M, Holm R, Reppas C, Symilllides M, Vertzoni M, Fotaki N
    Keywords: dose selection, formulation design, mechanistic absorption modeling, PBPK model, pediatricsSoftware: GastroPlus®Publication: J Pharm Pharmacol

    Objectives

    In this review, the current biopharmaceutical approaches for evaluation of oral formulation performance in paediatrics are discussed.

     

    Click Here to View

    Contact Us About This Journal Article

    Similar Resources

    Simulations Plus Journal Article
    05/26/2022
    Chronotherapy based on modified-release hydrocortisone to restore the physiological cortisol diurnal rhythm
    Whitaker MJ, Huatan H, Ross RJ
    Keywords: extended release, formulation design, gastroplus, mechanistic absorption model, pbbm, physiologically based biopharmaceutics modelingSoftware: GastroPlus®
    Read More Click Here to View
    Simulations Plus Poster
    03/27/2022
    Modeling of Indinavir-Induced Crystal Nephropathy in RENAsym®
    Bhargava P, Tallapaka SB, Woodhead JL
    Keywords: Acute kidney injury (AKI), crystal nephropathy, Indinavir, PBPK model, QST, Quantitative Systems Toxicology (QST), RENAsymSoftware: RENAsym®Conference: SOTDivision: DILIsym Services
    Read More Click Here to View
    Simulations Plus Presentation
    03/09/2022
    Patient-Centric Design of Long-Acting Injectable Drug Products
    Lukacova V
    Keywords: drug products, in vivo dissolution, long-acting injectable formulations, PBPK modelConference: AAPSDivision: Simulations Plus
    Read More Click Here to View