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    May 1, 2009
      |  Journal Article

    Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products

    Okumu A, DiMaso M, Loebenberg R
    Keywords: Caco-2 cells, computer simulation, dosage, drug delivery, humans, hydrogen-ion concentration, permeability, pharmaceutical chemistry, pharmaceutical preparations, Pyridines, solubility, Sulfones, therapeutic equivalency, x-ray diffractionSoftware: GastroPlus®Publication: Eur J Pharm Biopharm

    Purpose

    The purpose of this study was to compare the dissolution behaviour of etoricoxib in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using computer simulations.

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