Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products

Authors: Okumu A, DiMaso M, Loebenberg R
Publication: Eur J Pharm Biopharm
Keywords: Caco-2 cells, computer simulation, dosage, drug delivery, humans, hydrogen-ion concentration, permeability, pharmaceutical chemistry, pharmaceutical preparations, Pyridines, solubility, Sulfones, therapeutic equivalency, x-ray diffraction
Software: GastroPlus®

Purpose

The purpose of this study was to compare the dissolution behaviour of etoricoxib in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using computer simulations.