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Mar 9, 2022
  |  Presentation

Current status and gaps in mechanistic in-silico modeling for clinical translation and performance

Outline

  • PBPK model description
  • Exploring mechanisms affecting in vivo dissolution of low-solubility compound crystalline suspensions
    • Effect of inflammation
    • Example Paliperidone Palmitate
    • Effect of dissolution rate
    • Example Cabotegravir
  • Putting it all together

By Viera Lukacova

Presented at AAPS “Patient-Centric Design of Long-Acting Injectable Drug Products” Workshop Virtual Event March 9-10, 2022

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