Development of a PBPK Model for Mesalamine Using ACATPlus to Support Prediction of Local Gut Tissue Exposure

Authors: Plait F, Amaral Silva D, Fotaki N, Zhou H, Wu F
Conference: DMDG
Keywords: ACATPlus, DMDG 2026, gastroplus, gut tissue exposure, mesalamine, PBPK model
Software: GastroPlus®
Purpose
  • Mesalamine is a locally acting anti-inflammatory drug used to treat inflammatory bowel disease, where efficacy depends on achieving adequate concentrations in the terminal ileum and colonic tissues.
  • Predicting local gut tissue exposure remains challenging because conventional PBPK models primarily describe systemic plasma pharmacokinetics (PK).

By Fiona Plait, Daniela Silva, Nikoletta Fotaki, Haiying Zhou, Fang Wu

DMDG–GMP–SPS Joint Meeting 2026, October 5-7, 2026, Prague, Czezchia