February 2024 GastroPlus Newsletter

Authors: O’Connor D
Software: GastroPlus®

It’s cold, snowy, rainy, and dark…everything we expect in winter. But we have some news to share that may both warm and brighten your research day!We just released GastroPlus® 9.9!Key enhancements include:

  • Expanded the ocular (OCAT™), oral cavity (OCCAT™), and dermal (TCAT™) models by adding new formulations and PK/PD mechanisms to better capture local and systemic exposure levels in animals and humans
  • Extended the ACAT™ model to enhance the evaluation of formulation approaches for local gastrointestinal (GI) disease states
  • Improved Biologics Module features to mimic study designs and refine dose optimization simulations for clinical trial success
  • Upgraded with ADMET Predictor® version 11 models, enhancing our First in Human Simulator

To learn more download the GastroPlus 9.9 Flyer.If you need help to download the new version…just ask!  Upcoming Webinars:Unlocking the Power of PBPK Modeling: PBPK for First-in-Human and Beyond – March 20 Becky Graves, Director of Simulation Studies at Simulations Plus, will explain how to leverage the FIH Simulator to gain these insights and more. She’ll walk through physiologically based pharmacokinetic (PBPK) best practices, and how you can build PBPK models to translate nonclinical data to accurately design your FIH clinical trial and beyond.

ADMET Predictor® User Group Meeting – March 26-27 For our early discovery colleagues please consider joining us for the ADMET Predictor User Group meeting. Over two days, ADMET Predictor users will have the opportunity to hear user case studies, Simulations Plus presentations, and panel discussions about the future development of ADMET Predictor.

Winter Workshops:  We’re hosting another GastroPlus® workshop giveaway!Two lucky winners (one commercial and one academic) will be chosen at random. To enter the contest, please go to our LinkedIn post. The contest will run from Feb. 5-23 so submit your entry today! Winners will be notified via LinkedIn on Feb. 28.


  • Introductory GastroPlus® Workshop: Mumbai, India


  • Advanced GastroPlus DMPK & Clinical Pharmacology Workshop (Virtual)
  • PBPK Modeling for FIH Predictions: Virtual Workshop
  • Complimentary Introduction to GastroPlus® Workshop
  • GastroPlus Introductory Workshop
  • Introductory and Advanced Pharmaceutical Development Workshop Bundle
  • GastroPlus Application-Based DDI Workshop
  • GastroPlus Advanced Workshop: Pharmaceutical Development
  • PAGE Pre-conference Workshop: Introduction to GPX™  (in-person)

Lastly, for those of you on the East Coast of the US, please mark your calendars!I will be attending the 2024 NERDG Annual Meeting on Friday, March 22, 2024, at Mystic Marriott Hotel, in Groton, CT. We will be highlighting the upcoming GastroPlus platform…GPX! If you are available, it is a great small-format meeting and I’d love to connect with you there!Please let me know if you need any help advancing modeling and simulation with your teams.Happy Winter.