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Dec 1, 2016

Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

Objectives

The aim of this study was (1) to determine how closely physiologically based pharmacokinetic (PBPK) models can predict oral bioavailability using a priori knowledge of drug-specific properties and (2) to examine the influence of the biopharmaceutics classification system class on the simulation success.

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