Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

Authors: Hansmann S, Darwich AS, Margolskee A, Aarons L, Dressman J
Publication: J Pharm Pharmacol
Keywords: absorption, bioavailability, biopharmaceutics classification system, permeability, physiologically based pharmacokinetics
Software: GastroPlus®

Objectives

The aim of this study was (1) to determine how closely physiologically based pharmacokinetic (PBPK) models can predict oral bioavailability using a priori knowledge of drug-specific properties and (2) to examine the influence of the biopharmaceutics classification system class on the simulation success.