Mechanisms Underlying Species Differences in Hepatotoxicity

Authors: Watkins PB
Conference: AAPS
Keywords: bile acid transporters, drug-induced liver injury, hepatotoxicity, mitochondrial toxicity, Quantitative Systems Toxicology (QST)
Software: DILIsym®
Division: DILIsym Services

Outline of Talk

  1. The DILI-sim Initiative
  2. Applications to understanding species differences
    1.  AMG 009
    2. CKA
    3. troglitazone
  3. Conclusions

2018 AAPS Annual Meeting PharmSci 360, November 4-7, 2018, Washington, DC

By Paul B Watkins