Oral Absorption DDI Assessment Using PBPK, AI & Regulatory Perspective

Authors: Fraczkiewicz G
Conference: AAPS
Keywords: AAPS 2026, DDIs, drug development, gastroplus, GLP-1 agonists, modeling and simulation, oral absorption, PBPK modeling
Software: GastroPlus®
Session Description and Objectives
  • Oral absorption-mediated drug-drug interactions (DDIs) are important in drug development. PBPK modeling provides a mechanistic approach to predict interactions resulting from changes in gastric pH, altered gastric and intestinal transit, and food effects. This presentation highlights recent PBPK applications, including pH-dependent DDIs, transit changes related to GLP-1 receptor agonists, and food effects. Case studies will demonstrate regulatory applications, and we will discuss emerging AI approaches.
  • Upon completion, participants will be able to understand what absorption-related DDIs are and their potential impact on absorption and PK of orally administered drugs.
  • Understand how PBPK modeling can help to assess absorption-mediated DDIs, such as pH-dependent interactions, food effects, and gastric emptying prolongation due to GLP-1 agonists.
  • Understand the role of PBPK M&S in informing study design and regulatory decisions.

By Grazyna (Grace) Fraczkiewicz

AAPS PharmSci 360 2026, October 25-28, 2026, New Orleans, Louisiana