Using in-silico Models to Integrate in-vitro Data to Support Virtual Trials for Cost Effective Drug Development

Authors: Lukacova V
Conference: AAPS
Keywords: dissolution, drug development, in silico models, in vitro, PBPK model, pharmacokinetics
Software: GastroPlus®
Division: Simulations Plus

Outline

• What is PBPK model?
• Parameterizing PBPK model using in vitro data
• Dissolution & Precipitation
• Passive Absorption
• Pharmacokinetics
• Virtual Trials: Applications of calibrated PBPK model
• Summary

2018 AAPS Annual Meeting PharmSci 360, November 4-7, 2018, Washington, DC

By Viera Lukacova