In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems.

Publication: Drug Dev Ind Pharm
Software: GastroPlus®

Objective

The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also to identify the optimal place in the gastrointestinal (GI) tract for the release of SV using coupled in vitro/in silico approach.