Discovery Toxicology 2024 – “Emerging predictive toxicology capabilities across modalities”

DiscoTox2024 is a free a one-day event in association with the British Society of Toxicology focused on discovery safety strategies for new modalities: what’s new from small molecules to cell and gene therapies. DiscoTox2024 is a face-to-face event, designed to explore the latest cutting-edge approaches to navigate through the Discovery Toxicology landscape.

Closing Keynote

Title: BIOLOGXsym – Use of Liver MPS and QST modeling to simulate biologics-inducded liver injury
Presenter: Senior Principal Scientist, QSP, Kyunghee Yang, Ph.D.
Date/Time: June 12, 2024 from 3:45pm – 4:30pm BST

Quantitative systems toxicology (QST) modeling incorporates dynamic pharmacokinetic exposure and drugs’ ability to alter key hepatocyte pathways, informed by mechanistic studies from human-derived in vitro systems, to predict the frequency and severity of drug-induced liver injury (DILI) in simulated patient populations. In vitro human microphysiology systems are 3D tissue/organ biomimetics that can further improve our mechanistic understanding about hepatotoxicity mediated by small molecules as well as biologics. In this talk, application of QST modeling and mechanistic toxicity data from Liver Acinus MicroPhysiology System (LAMPS) to investigate biologics-mediated hepatotoxicity will be presented using tocilizumab as a case study.