Formulation and Evaluation of Poly(Jasmine Lactone) Based Micelles for Improving the Oral Permeability of Acyclovir

Formulation and Evaluation of Poly(Jasmine Lactone) Based Micelles for Improving the Oral Permeability of Acyclovir

Authors: Verma J, Frejborg F, Mantegna M, Kumar V, Hukkanen V, Flaten GE, Rosenholm JM, Bansal KK
Publication: Eur J Pharm Sci
Keywords: gastroplus, herpes simplex virus, improved permeability, oral delivery, Poly(jasmine lactone), polymeric micelles, PVPA
Software: GastroPlus®

Acyclovir (ACV), an antiviral drug, belongs to the BCS class III drug with intermediate solubility and low permeability.

Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain

Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain

Authors: Taneja A, Troconiz F, Danhof M,
Publication: Pharm Res
Keywords: Gabapentin, mechanistic modeling, rat model
Division: PBPK

The formalin-induced rat model of nociception involves moderate continuous pain. Formalin-induced pain results in a typical repetitive flinching behaviour, which displays a biphasic pattern characterised by peaks of pain.