This video shows how to set up enterohepatic circulation of ezetimibe in order to accurately simulate the in vivo plasma protein concentration.
Parameter Sensitivity Analysis in GastroPlus®
This video describes how to set up a parameter sensitivity analysis (PSA) in GastroPlus.
Ionization effects in GastroPlus®
This video discusses how the ionization of a molecule effects its dissolution and absorption.
Using Liver Microsomal clearance in GastroPlus®
This video demonstrates how to enter liver microsomal data into GastroPlus with the unit converter and importing the values during structure input.
Adding OATP and MRP-2 transporters to PBPK models in GastroPlus®
This video shows how to add OATP and MRP-2 transporter kinetics to PBPK models.
Converting In Vitro Permeability to Effective Jejunum Permeabililty
This video is a demonstration of Tutorial 5.3.3. It shows how to create a correlation between apparent permeability and effective jejunum permeability.
Tracking Metoprolol Metabolites in GastroPlus® 9.5
This video shows how to track the metabolites of metoprolol in GastroPlus 9.5.
Tracking Metabolites in GastroPlus®
This video shows how to track the N-debutyl metabolite of dronedarone in GastroPlus.
GastroPlus® ADMET Predictor Module
This video shows features available in MedChem Designer™ that are available for users that license the ADMET Predictor™ module within GastroPlus™.
GastroPlus 9 Installation
This video shows how to install GastroPlus and the Flexera licensing system. The installation is the same for various versions.
Application of Cellular Permeability Simulation and PBPK Models to Capture Significance of Transporter Effects on Dose Linearity
In this GastroPlus™ User Group webinar, we will discuss the validation of passive permeability estimates in MembranePlus for a library of diverse compounds and describe the application of MembranePlus to fit intracellular efflux transporter affinity (Km) for GastroPlus™ PBPK models.
Improving Bioavailability During Lead Optimization Using Global Sensitivity Analysis of Physiologically-Based Pharmacokinetics Modeling
In this presentation, Dr. Eric Martin of Novartis discusses improving bioavailability during lead optimization using global sensitivity analysis (GSA) of physiologically based pharmacokinetics in GastroPlus.
bayer pka
This GastroPlus™ User Group webinar will focus on special considerations when performing pediatric PBPK modeling in GastroPlus™ Presented by Dr. Viera Lukacova.
User Customized Biotransformations with MedChem StudioTMand MedChem DesignerTM
This video illustrates features in MedChem Studio and MedChem Designer that allow one to create customized biotransformation reactions. A glucuronidation reaction illustrating phase II metabolism is shown as an example.