Covariates are used to explain intra-individual variability of population parameters.
Feature of the week #69: Sycomore
We know that development of a good model is a long process of incremental improvements.
GastroPlus® User Group Webinar: Physiologically Based Pharmacokinetic Modelling for First‑In‑Human Predictions
This webinar provides an overview of a recent publication on physiologically based pharmacokinetic (PBPK) modeling in first in human (FIH) predictions, and this was a collaborative effort from GastroPlus® User Group members.
Feature of the week #68: Scripting Monolix in R
Sometimes you might want to use Monolix through the interface but with scripts, for example to automate a set of actions in Monolix.
Case study: PK/PD modeling using the simultaneous, sequential or intermediate approach (Maryland 3)
The aim of this tutorial is to show how to develop a pharmacokinetic-pharmacodynamic (PKPD) model.
Case study: PK model development for a multi-dose study (Maryland 2)
The aim of this tutorial is to develop a population PK model for a multiple dosing trial study of a hypothetical test drug used in the...
Case study: PK model development and covariate exploration (Maryland 1)
The aim of this tutorial is to develop a population PK model and explore covariate relationships of a hypothetical test drug used in the treatment of atrial fibrillation.
Using ADMET Predictor® v9.5 to support medicinal chemistry programs User scenarios and examples
Simulations Plus hosts a webinar to introduce how ADMET Predictor® can be used efficiently to support medicinal chemistry programs in drug discovery.
Feature of the week #67: Graphical results of NCA in PKanalix
PKanalix can be used for efficient non-compartmental and compartmental analysis.
Feature of the week #66: Interpreting the PD versus PK plot – the example of hysteresis
When several types of observations are recorded in the data set, Datxplore allows to plot one type versus another one.
Feature of the week #65: Time-to-event modeling with Monolix
Monolix uses a parametric approach to model time-to-event data, via the definition of a hazard function.
Feature of the week #64: Inter-occasion variability in Monolix
Mixed effects models can take into account several levels of variability.
Grill the GastroPlus® Gurus Webinar
This webinar with a panel of experienced GastroPlus users aims at providing users, both new and more experienced, with tips and tricks to improve their use of GastroPlus.
PKPlus™ 2.5 Release Webinar
Learn about the latest developments in PKPlus™
GastroPlus® User Group Webinar: Applications/Experiences of PBPK Modeling to Support Regulatory Interactions
Recent experiences with PBPK model-based regulatory submissions used to obtain product development and DDI waivers will be discussed.
Support files in GastroPlus®
This video discusses support files in GastroPlus™.
The GastroPlus® Batch Simulation Mode
This video describes the batch simulation mode in GastroPlus.
The Optimization Module in GastroPlus®
This tutorial discusses the Optimization module in GastroPlus that allows one to optimize simulation model parameters such as initial dose, Vmax, enzyme expression levels, and many others, in order to...
Enzyme and Transporter Expression Levels in GastroPlus® 9.6
This video discusses the enzyme and transporter expression levels that are defined in various tissues, e.g., GI tract, liver, lung, kidney and species (human, dog, monkey, and rat).
The PKPlus Module in GastroPlus® Tutorial
This video shows how to create noncompartment, 1-, 2-, and 3-compartment pharmacokinetic models based on in vivo data using the PKPlus™ module in GastroPlus.