Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs.
Keywords: aerosol, deposition, dissolution, drug delivery, inhalation, lung, PBPK, pcat, permeation, pulmonary, respiratorySoftware: GastroPlus®Publication: Eur J Pharm Sci
Abstract
Prediction of local exposure following inhalation of a locally acting pulmonary drug is central to the successful development of novel inhaled medicines, as well as generic equivalents. This work provides a comprehensive review of the state of the art with respect to multiscale computer models designed to provide a mechanistic prediction of local and systemic drug exposure following inhalation. The availability and quality of underpinning in vivo and in vitro data informing the computer based models is also considered.
