An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury
N-acetylcysteine (NAC) is the treatment of choice for acetaminophen poisoning; standard 72-h oral or 21-h intravenous protocols are most frequently used.
Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding
Hepatitis C virus (HCV) entry is a multiple-step process involving a number of host factors and hence represents a promising target for new antiviral drug development.
Translation of drug effects from experimental models of neuropathic pain and analgesia to humans
Neuropathic pain research remains a challenging undertaking owing to: (i) the lack of understanding about the underlying disease processes; and (ii) poor...
Prediction of acute mammalian toxicity using QSAR methods: a case study of sulfur mustard and its breakdown products
Predicting toxicity quantitatively, using Quantitative Structure Activity Relationships (QSAR), has matured over recent years to the point that the predictions can be used to help identify missing comparison...
Simulations Plus Announces Next Quarterly Cash Dividend
Company declares cash dividend of $0.05 per share
Developing In Vitro–In Vivo Correlation of Risperidone Immediate Release Tablet
The present study was aimed to predict the absorption profile of a risperidone immediate release tablet (IR) and to develop the level A in vitro–in vivo correlation (IVIVC) of the drug using...
In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen
The FDA Biopharmaceutical Classification System guidance allows waivers for in vivobioavailability and bioequivalence studies for immediate-release solid oral...
Simulations Plus Reports 3rd Quarter and First 9 Months FY2012 Financial Results
3rd quarter sales increase 5.0% to $2.77 million; 9 months net income up 5.9% to $2.68 million
Simulations Plus Sets Date for 3rd Quarter 2012 Earnings Release and Conference Call
Conference Call to Be on Thursday, July 12, at 4:15 PM ET
Simulations Plus Expands Marketing and Sales Staff
Ms. Anu Sharma Joins the Company as Senior Sales and Marketing Manager, focusing on Cheminformatics Products
Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid
Ethanol intake can lead to an unexpected and possibly problematic increase in the bioavailability of druglike compounds. In this work we investigated the effect of ethanol on the apparent solubility...
Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset
To develop a computational model for predicting CNS drug exposure using a novel in vivo dataset.
Simulations Plus Signs Additional Collaboration Agreement
Major Pharmaceutical Company to Fund Transdermal and Subcutaneous Drug Absorption Model in GastroPlus
Simulations Plus Signs Collaboration Agreement
Major Pharmaceutical Company to Fund Enhanced Oral Cavity Model in GastroPlus™
Simulations Plus Reports Preliminary Third Quarter FY2012 Results
Net sales increase 4.9% to new 3rd quarter record of $2.77 million
Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions
Patupilone (EPO906) is a novel potent microtubule stabilizer, which has been evaluated for cancer treatment. A novel physiologically based pharmacokinetics (PBPK) model was developed...
Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug- Drug Interactions
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions.
Clinical outcome in patients receiving systemic therapy for metastatic sarcomatoid renal cell carcinoma: a retrospective analysis
Objectives: Sarcomatoid metastatic renal cell carcinoma (mRCC) represents an aggressive subset of disease, and a definitive therapeutic strategy is lacking. We seek to define...
Tissue-selective regulation of androgen-responsive genes
Introduction: Androgens regulate a wide array of physiological processes, including male sexual development, bone and muscle growth, and behavior and cognition. Because...