Background: Methotrexate (MTX) is associated with several side effects, including hepatic and renal toxicities, which limit its effectiveness as an anticancer medication. These toxicities can lead to hepatotoxicity, nephrotoxicity, and potential liver and kidney failure. On the other hand, the fruit of the giant fennel plant (Ferula communis) contains bioactive compounds with proven antioxidant and anti-inflammatory properties, as demonstrated in previous studies. These compounds have protective effects against various diseases.

By Ghizlane Nouioura, Mohamed El Fadili, Mohamed Bouhrim, El Hassania Loukili, Hazem K. Ghneim, Mourad A. M. Aboul-Soud, John P. Giesy, Badiaa Lyoussi, Elhoussine Derwich