Physiologically Based Pharmacokinetic Simulations Using Transdermal Compartmental Absorption and Transit Model (TCAT) for RLS-1496 Dermal Preparations

Authors: Mollo R, Moreno R, Vora TB
Conference: AAPS
Keywords: AAPS 2025, dermal, gastroplus, PBPK, tcat, Transdermal Compartmental Absorption & Transit (TCAT™)
Software: GastroPlus®

Purpose

  • RLS-1496 is a senolytic drug formulated as a cream for topical administration and currently in Phase 1 clinical trials for dermatological conditions. A 1% cream strength was determined to be a safe starting dose for first-in-human studies, based onnonclinical toxicology studies.
  • In this work, we present the application of PBPK modelling, employing a transdermal compartmental absorption and transit (TCAT) model in GastroPlus®, to support formulation changes and simulate concentrations in the skin compartments resulting from the administration of the 1% cream in a clinical setting.

By Rosario Mollo, Ofir Moreno, Tarang Vora

American Association of Pharmaceutical Scientists (AAPS) PharmSci360, November 9-12, 2018, San Antonio, TX