Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus” or the “Company”), a leading provider of cheminformatics, biosimulation, simulation-enabled performance and intelligence solutions, and medical communications to the biopharma industry, today announced preliminary results for its fiscal year 2025 and issued preliminary guidance and management outlook for fiscal year 2026 as follows:

The fiscal 2025 preliminary results and fiscal 2026 guidance set forth above are preliminary and unaudited based on currently available information and management estimates and are subject to adjustment in the final audited financial statements to be filed with the Company’s Annual Report on Form 10-K for the full fiscal year 2025, expected to be filed on December 1, 2025.

“We expect to successfully meet our revised fiscal 2025 guidance despite operating in a challenging market environment shaped by ongoing uncertainty around funding, drug pricing, and tariffs affecting both our pharmaceutical and biotech clients,” said Shawn O’Connor, Chief Executive Officer of Simulations Plus. “Looking ahead, we are issuing preliminary guidance for fiscal 2026 based on the assumption that current market conditions remain stable.

“As part of our ongoing commitment to innovation, we are excited to unveil our new product vision, which is designed to accelerate delivery of software enhancements, deepen platform integration, and advance our AI capabilities. The recent launch of GastroPlus® X.2 (GPX.2) marks the debut of our AI-powered tools on the S+ Cloud—an important first step in our broader, integrated Cloud and AI strategy. Over the next year, we plan to expand these capabilities across our other flagship platforms, delivering greater value to our clients through enhanced productivity, richer data insights, and streamlined decision support. We look forward to sharing additional details when we report our fiscal 2025 results in December.”

Upcoming Investor Events

Shawn O’Connor will be participating in the following investor events:

KeyBanc Non-Deal Roadshow
Format: One-on-one meetings
When: Tuesday, October 28, 2025
Location: Virtual

Stephens Annual Investment Conference 2025
Format: Fireside chat and one-on-one meetings
When: Wednesday, November 19, 2025, at 2:00 PM ET
Location: Nashville, Tennessee

BTIG Digital Health Forum
Format: Fireside chat, thematic panel, and one-on-one meetings
When: Monday, November 24, 2025, at 2:00 PM ET
Location: Virtual

TD Cowen 3^rd Annual Diagnosing Tomorrow Conference: Tools & Technologies for the Next Decade
Format: Fireside chat and one-on-one meetings
When: Thursday, December 11, 2025, more details to follow
Location: New York City

For more information about the events or questions about registration, interested parties should visit the investor relations page of the Simulations Plus website or reach out to their contacts at the sponsoring firms.

Fourth Quarter and Fiscal 2025 Press Release, Webcast, and Conference Call Details

The Company will report fourth quarter and fiscal 2025 financial results after the market close on Monday, December 1, 2025.

Shawn O’Connor, Chief Executive Officer, and Will Frederick, Executive Vice President and Chief Financial Officer, will host a conference call and webcast on the same day at 5:00 p.m. Eastern Time to discuss the results and certain forward-looking information. The call may be accessed by registering here or by calling 1-877-451-6152 (domestic) or 1-201-389-0879 (international). The webcast can be accessed on the investor relations page of the Simulations Plus website https://www.simulations-plus.com/investorscorporate-profile/corporate-profile/ where it will also be available for replay approximately one hour following the call.