Unlock the efficiency of the ADMET Predictor® command line on both Windows and Linux platforms. This video demonstrates how to execute property predictions without the GUI, using SMILES, SDF, and XTK files. Key technical coverage includes configuring multi-threading with the -n option for faster batch processing, specifying pH-dependent solubility with -P, and generating Out of Scope (OTS) and Uncertainty (UNC) files for model validation. The tutorial goes into depth on the -W workflow flag, showing how to tailor output for different professional roles—such as predicting dominant ionization states at specific pH levels for docking studies or displaying full pKa microstate distributions for physical chemistry analysis.