Chimeric antigen receptor T-cell (CAR-T) therapies have revolutionized the treatment of hematologic malignancies, delivering durable responses in patients with relapsed and refractory cancers. However, the unique pharmacological behavior of these living drugs poses significant challenges for clinical pharmacology and model-informed drug development.

This webinar offers a comprehensive overview of the unique kinetics and pharmacodynamic characteristics of CAR-T therapies, including multiphasic kinetics, clinical pharmacology considerations, modeling strategies, exposure-response complexities, and the evolving landscape of CAR-T design. Through the lens of model-informed drug development, the presenters will explore how Monolix, a powerful nonlinear mixed-effects modeling platform, can be used to characterize CAR-T kinetics and pharmacodynamics.

Attendees will also see a practical case study on modeling Tisagenlecleucel, covering model development, data integration, and interpretation of results to inform clinical decision-making.

This webinar is ideal for clinical pharmacologists, modelers, translational scientists, and regulatory professionals seeking to deepen their approach to CAR-T development through quantitative modeling.

Register now to save your spot.

Presenters:

• Mitali Gaurav – Assistant Director, Pharmacometrics, Scientific Staff
• Nancy Lin – Pharmacometrician I, Scientific Staff
• Pauline Traynard – Director, Scientific Product Enablement, Product Development