The PBPK Spring School is designed for beginner modelers willing to learn the basics of PBBM-PBPK modeling and to go further using this concept in GastroPlus. Over five intensive sessions you’ll learn how to simulate an API distribution and elimination following intravenous administration using a compartmental model, setup parameters influencing absorption, and use your validated PBBM-PBPK models to perform Virtual Bioequivalence for immediate and controlled released drug products. You will also learn how to assess Food effect using GastroPlus. More than a software tutorial, this course gives you the framework, skills and mindset to support Biopharmaceutics applications, and regulatory decisions.

You’ll see not only “how” to use novel GastroPlus features but “why” they must be utilized in a certain order, to support your PBBM-PBPK model endeavor. With hands-on exercises, live expert guidance, and a free temporary GastroPlus™ license, you’ll be able to experiment directly on your own projects and bring back immediately usable workflows to your team.

• Session 1: Getting Started with GastroPlus: Building a Solution PBPK Model
• Session 2: From Solubility to Dissolution: Fundamentals for Oral Drug Absorption Modeling
• Session 3: PBBM-PBPK model for Immediate Release Drug Products
• Session 4: PBBM-Based IVIVC for Controlled Release Drug Products
• Session 5: Assessing Food Effects on PK: A PBPK Modeling Approach