Live Q&A with James Clary, Jeff Woodhead, Lara Clemens, Lisl Shoda, Maxime LeMerdy, Nader Hamzavi, Scott Q. Siler.
![Discovery Track: Pushing the Boundaries Beyond – NextGen Session Panel Discussion and Live Q&A](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Discovery Track: Pushing the Boundaries Beyond – NextGen Session Panel Discussion and Live Q&A
Live Q&A with David Miller, Marvin Waldman, Michael Lawless, Pankaj R. Daga, Phyo Phyo Kyaw Zin, and Robert Fraczkiewicz.
![Pre-Clinical Track Poster Presentation: Simulations using BIOLOGXsym demonstrate hepatotoxic potential of Tocilizumab through both on- and off-target effects](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Pre-Clinical Track Poster Presentation: Simulations using BIOLOGXsym demonstrate hepatotoxic potential of Tocilizumab through both on- and off-target effects
Presented by Lara Clemens at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Discovery Track Poster Presentation: Modeling tautomer preference](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Discovery Track Poster Presentation: Modeling tautomer preference
Presented by Marvin Waldman at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Pre-Clinical Track Poster Presentation: QST Modeling of Drug Induced Acute Proximal Tubule Epithelial Cell Injury and Associated Renal Hemodynamic Responses](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Pre-Clinical Track Poster Presentation: QST Modeling of Drug Induced Acute Proximal Tubule Epithelial Cell Injury and Associated Renal Hemodynamic Responses
Presented by Nader Hamzavi at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Discovery Track: How we leverage automation for data mining, preprocessing & curation](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Discovery Track: How we leverage automation for data mining, preprocessing & curation
Presented by Phyo Phyo Kyaw Zin at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Pre-Clinical Track: Ophthalmic clinical pharmacokinetic/pharmacodynamic prediction using PBPK model validated against preclinical datasets](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Pre-Clinical Track: Ophthalmic clinical pharmacokinetic/pharmacodynamic prediction using PBPK model validated against preclinical datasets
Presented by Maxime LeMerdy at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Discovery Track: AIDD with external models](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Discovery Track: AIDD with external models
Presented by Michael Lawless at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Pre-Clinical Track: Translational Modeling of Relapsing Mouse Models to Inform Regimen Selection in Tuberculosis](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Pre-Clinical Track: Translational Modeling of Relapsing Mouse Models to Inform Regimen Selection in Tuberculosis
Presented by James Clary at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Discovery Track: Modeling CYP sites of metabolism in ADMET™ Predictor](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Discovery Track: Modeling CYP sites of metabolism in ADMET™ Predictor
Presented by Pankaj R. Daga at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Simulations Plus University+ Program](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus University+ Program
The University+ program offers one-year access to Simulations Plus software to students and educators at accredited universities worldwide. Learn more from Divisional President, John DiBella.
![Discovery Track: HTPK simulations using the new REST API + platform update](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Discovery Track: HTPK simulations using the new REST API + platform update
Presented at SLP MIDD+ Virtual Conference February 16th-17th, 2022
![Welcome to the 2022 MIDD+ Scientific Conference and Keynote Speaker](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Welcome to the 2022 MIDD+ Scientific Conference and Keynote Speaker
Welcome and Introductions hosted by Arlene Padron.
![Capturing Interpatient Variability with SimPops](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Capturing Interpatient Variability with SimPops
SimPops provide significant value for drug development. "The SimPops are the Crown Jewel".
![In Vivo Extrapolation of Precipitation with Complex Dissolution Experiments](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
In Vivo Extrapolation of Precipitation with Complex Dissolution Experiments
DDDPlus provides complex models to handle: membrane dissolution, biphasic dissolution and artificial stomach duodenum test.
![Applicability of Existing Prediction Methods to Non-Oral Routes of Delivery](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Applicability of Existing Prediction Methods to Non-Oral Routes of Delivery
Discuss advances made with PBPK modeling for both oral and non-oral routes for the first in human predictions
![MIDD in Preclinical Drug Development](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
MIDD in Preclinical Drug Development
Providing a case for why you should focus on preclinical verification when using Physiologically Based Pharmacokinetic (PBPK) modeling for First-In-Human (F.I.H) pharmacokinetic predictions.
![RENAsym, a QST Model to Predict Drug-Induced Kidney Injury](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
RENAsym, a QST Model to Predict Drug-Induced Kidney Injury
Drug-induced kidney injury or acute kidney injury (AKI) is one of the major reasons for drug failure behind cardiovascular and liver injuries
![Mathematical Modeling in Industry: Building Models to Advance Drug Development](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Mathematical Modeling in Industry: Building Models to Advance Drug Development
QSP models are designed to characterize biological systems, representing details such as disease pathophysiology, drug pharmacology, and pathways of toxicity