This tutorial for ADMET Predictor provides a deep dive into the HTPK (High-Throughput Pharmacokinetics) module. It covers the setup of oral and IV simulations using rat or human physiologies, running multi-dose comparisons (e.g., 1mg vs. 100mg) to identify concentration-dependent absorption, and interpreting complex PK output data including AUC, halflife, and volume of distribution. The video also features advanced data visualization techniques, such as identifying solubility-limited and permeability-limited compounds through 2D and 3D property projections, aligning with the BCS (Biopharmaceutics Classification System).
ADMET Predictor® Tutorial Series: HTPK Part 1
Authors:
Jamois E
Keywords:
admet predictor, clearance, Cmax, fraction absorbed, htpk simulation, oral bioavailability, percent FA, percent FB, pharmacokinetic prediction, solubility-limited absorption, Tmax
Software:
ADMET Predictor®
Division:
Cheminformatics