This tutorial for MedChem Studio™ (ADMET Predictor®) provides advanced workflows for lead optimization and library design. Learn to use the Find Best Subsets tool to automatically identify compound groups that optimize properties like solubility or ADMET Risk. The video details how to refine scaffolds using Maximum Common Substructure (MCS) and perform Matched Molecular Pair (MMP) analysis to identify “property cliffs”—small chemical changes that result in dramatic property shifts. These techniques are essential for chemists aiming to prioritize synthetic targets based on predicted ADMET profiles.