This tutorial for ADMET Predictor explores advanced model management and validation techniques. You will learn how to use the Model Editor to turn specific models on or off, define user models, and understand the technical parameters behind PLS and ANN ensembles. The guide covers how to handle out-of-scope predictions, perform structural modifications to optimize ADMET properties using SSA, and use confidence estimates to assess the reliability of classification models. Finally, it demonstrates how to integrate regression uncertainty with GastroPlus® simulations to perform parameter sensitivity analysis.