From Bench to Computational Modeling: Integrating Mitochondrial Stress Data from a Rat Hepatic Ischemia-Reperfusion Injury Model into a Preclinical and Human Quantitative Systems Toxicology Platform

Authors: Kim J, Beaudoin J, Hong SK, Zielonka J
Conference: AASLD
Keywords: AASLD liver meeting, DILIsym, hepatic ischemia-reperfusion injury (IRI), liver dysfunction, Quantitative Systems Toxicology (QST)
Software: DILIsym®

Background

  • Hepatic ischemia-reperfusion injury (IRI) contributes significantly to liver dysfunction post-surgery and transplantation
  • Mitochondrial, oxidative, and inflammatory processes are central to IRI pathology
  • Quantitative systems toxicology (QST) modeling integrates mechanistic data to simulate injury dynamics and assess biomarkers or therapies

By Joohyun Kim, James J Beaudoin, Seung-Keun Hong, Jacek Zielonka

American Association for the Study of Liver Diseases (AASLD) Liver Meeting 2025, Washington, DC., November 7-11, 2025