Introducing GastroPlus X.2: AI, Automation, Insights & More

Authors: Miller N, Graves B
Keywords: ACAT model, gastroplus, GPx, GPX.2, pbbm, PBPK modeling
Software: GastroPlus®
Division: PBPK

Get a first look at game-changing new functionality that will revolutionize your PBPK/PBBM modeling. Our experts introduce you to…

  • ACATPlusTM, the extension of the industry-leading ACAT™ model for understanding local drug disposition in the gastrointestinal tract
  • AssessmentsPlusTM, for efficiently building high-quality PBPK/PBBM models using embedded expert knowledge, including the option to enhance the advice with our finely-tuned large language model (LLM)
  • Distribution Dashboard, which provides mechanistic insight into the tissue binding in PBPK tissues and fitting the most relevant input parameter
  • Intramuscular and subcutaneous dosing, which have been incorporated into the GPX paradigm
  • Orchestrator, for automating GPX.2 workflows as well as extending functionality and plotting via R/Python
  • P-PSDTM, for fitting dissolution data using a product particle size distribution to represent the surface area of drug substance available for dissolution
  • Virtual replicate BE functionality, enhanced to include full and semi-replicate designs commonly used in bioequivalence studies