Modeling Drug Disposition in Ocular Tissues following Topical Eye Drops and Intravitreal Injection

Modeling Drug Disposition in Ocular Tissues following Topical Eye Drops and Intravitreal Injection

Conference: ARVO
Software: GastroPlus®
Division: Simulations Plus

The purpose of this study was to model the ocular absorption, distribution and clearance of clonidine and voriconazole from topical and intravitreal applications, respectively. Clonidine is a potent…

Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products

Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products

Publication: Eur J Pharm Biopharm
Software: GastroPlus®

The purpose of this study was to compare the dissolution behaviour of etoricoxib in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using computer simulations.

Pandora Internet Radio

Pandora Internet Radio

I found that I was getting into a musical rut and had a hard time finding new music I liked. Then I stumbled on Pandora Internet Radio. On Pandora, you create your own “radio station” by naming a favorite song or artist. Pandora scans thousands of pieces of music that have been analyzed by something called the Music Genome Project to identify those with similar attributes to the one you named. Voilà! New music for you to enjoy.

Living Tongues

Living Tongues

Languages, even seldom-used languages, can tell us a great deal about how a group of people categorize the natural and mental world, says Jeff Good, a linguistics professor at the State University of New York at Buffalo (1). Languages are rich in the history and taxonomy of a place, reflecting subtleties that can be lost in translation, says Greg Anderson, an ethnographer who directs Oregon’s Living Tongues Institute (2). When the last keepers of a language die off, so does the fluent understanding of that particular environment.

Non-competitive androgen receptor inhibition in vitro and in vivo

Non-competitive androgen receptor inhibition in vitro and in vivo

Publication: Proc Natl Acad Sci USA
Division: Simulations Plus

Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available...

How Jazz Hastened Civil Rights

How Jazz Hastened Civil Rights

Jazz had a largely unappreciated role in hastening the arrival of the civil rights movement, according to veteran jazz writer Nat Hentoff. As early as the 1920s, white and black jazz musicians played together in after-hours jam sessions. But it was not until the 1940s, Hentoff said in the January 15, 2009, issue of the Wall Street Journal, that jazz musicians and their audiences mixed publicly in clubs—tentatively at first, but then freely and openly, in violation of local laws and mores. As jazz captured more and more avid listeners, white Americans started to understand the effect of segregation in all aspects of American culture.

Development of a Steady-State Exposure-Response Model for Exenatide Once Weekly

Development of a Steady-State Exposure-Response Model for Exenatide Once Weekly

Conference: ASCPT
Division: Cognigen

Exenatide is dosed as a subcutaneous (SC) injection of 5 and 10 μg twice daily (BID) before main meals and is indicated for the treatment of type 2 diabetes mellitus in patients failing to achieve adequate…

Dan Carlin’s Hardcore History

Dan Carlin’s Hardcore History

In Dan Carlin’s Hardcore History podcasts, the past is twisted and turned upside down in novel and intriguing ways. Dan Carlin, a veteran journalist and radio talk show host, emphasizes the drama of past events and personalities to reveal why history matters today.

Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds

Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds

Publication: J Pharm Sci
Software: ADMET Predictor®

We first review the state-of-the-art in development of log P prediction approaches falling in two major categories: substructure-based and property-based methods.

Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci

Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci

Division: Cognigen

Correctly determined susceptibility breakpoints are important to both the individual patient and to society at large. A previously derived patient population...

Toward an In Vivo Dissolution Methodology: A Comparison of Phosphate and Bicarbonate Buffers

Toward an In Vivo Dissolution Methodology: A Comparison of Phosphate and Bicarbonate Buffers

Publication: Mol Pharm
Software: ADMET Predictor®

The purpose of this research was to evaluate the difference between the pharmaceutical phosphate buffers and the gastrointestinal bicarbonates in dissolution of ketoprofen and indomethacin...