One of the most important physicochemical properties of small molecules and macromolecules are the dissociation constants for any weakly acidic or basic groups...
Improving selective androgen receptor modulator discovery and preclinical evaluation
Background: Selective androgen receptor modulators (SARMs) represent a new class of pharmaceuticals that may find wide clinical use. However, selectivity is not understood...
Simulations Plus Subsidiary Receives Medicare Accreditation
Highest level of accreditation achieved after on-site inspection
Simulations Plus CEO to Present at Southern California Investor Conference
Presentation to be Webcast
Simulations Plus Releases ADMET Predictor™ Version 4.0
Latest Update to Best-in-Class Software Further Extends Lead over Competition
Simulation of Food Effect on Cilostazol Exposure in Human
For certain drugs, the time of administration respective to meal times can have a significant impact on exposure. The effect of food is usually attributed to increased solubility/dissolution rate and/or…
Simulations Plus Reports Third Quarter FY2009 Financial Results
Best-in-Class Pharmaceutical Software & Services Sales Remain Strong
Simulations Plus Sets Date for Third Quarter Fiscal Year 2009 Earnings Release and Conference Call
Conference Call to Be on Thursday, July 16, at 4:15 PM EDT
Improving the Efficiency and Ensuring the Quality of Data Assembly for Pharmacometric Analysis
Better tools and processes can improve the efficiency of data assembly and the quality of analysis-ready datasets for pharmacometric analyses.
Modeling and Simulation Approach to Pediatric Drug Development
Describe a process for determining pediatric drug doses using pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation.
Celebrating Globalization
The word “globalization” can be interpreted many ways, both positive and negative. In these uncertain economic times, many people think globalization is equivalent to job loss and trade protectionism.
Prediction of Dose-Dependent Intestinal and Liver First Pass Extraction for CYP3A4 Substrates
Cilostazol and midazolam absorption and pharmacokinetics were simulated using GastroPlus™. The program’s Advanced Compartmental and Transit model described the absorption and intestinal metabolism of both…
Simulations Plus Reports Preliminary Results for Third Fiscal Quarter
Company CEO to Present at New York City Investor Meeting and Webinar
Role of physiological intestinal water in oral absorption
Water volume has impact when the compound has low aqueous solubility. For example, the absorption of compounds with a Biopharmaceutics Classification System...
Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data
The aim of this study was to demonstrate the value of mechanistic simulations in gaining insight into the behaviors of modified release (MR) formulations in vivo and...
Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine
The purpose of this study was to develop simulation and modeling methods for the evaluation of pharmacokinetics when intestinal influx and efflux transporters are involved...
An investigation into the importance of “Very Rapid Dissolution” criteria for drug bioequivalence demonstration using gastrointestinal simulation technology
The Biopharmaceutics Classification System (BCS) is based on the mechanistic assumptions that the rate and extent of oral drug absorption are governed by drug solubility...