Simulation of Food Effect on Cilostazol Exposure in Human

Simulation of Food Effect on Cilostazol Exposure in Human

Conference: CRS
Division: Simulations Plus

For certain drugs, the time of administration respective to meal times can have a significant impact on exposure. The effect of food is usually attributed to increased solubility/dissolution rate and/or…

Improving the Efficiency and Ensuring the Quality of Data Assembly for Pharmacometric Analysis

Improving the Efficiency and Ensuring the Quality of Data Assembly for Pharmacometric Analysis

Conference: PAGE
Division: Cognigen

Better tools and processes can improve the efficiency of data assembly and the quality of analysis-ready datasets for pharmacometric analyses.

Modeling and Simulation Approach to Pediatric Drug Development

Modeling and Simulation Approach to Pediatric Drug Development

Conference: PAGE
Division: Cognigen

Describe a process for determining pediatric drug doses using pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation.

Celebrating Globalization

Celebrating Globalization

The word “globalization” can be interpreted many ways, both positive and negative. In these uncertain economic times, many people think globalization is equivalent to job loss and trade protectionism.

Prediction of Dose-Dependent Intestinal and Liver First Pass Extraction for CYP3A4 Substrates

Prediction of Dose-Dependent Intestinal and Liver First Pass Extraction for CYP3A4 Substrates

Conference: PharmSci Fair
Software: GastroPlus®
Division: Simulations Plus

Cilostazol and midazolam absorption and pharmacokinetics were simulated using GastroPlus™. The program’s Advanced Compartmental and Transit model described the absorption and intestinal metabolism of both…

Role of physiological intestinal water in oral absorption

Role of physiological intestinal water in oral absorption

Authors: Sutton SC
Publication: AAPS J
Software: GastroPlus®

Water volume has impact when the compound has low aqueous solubility. For example, the absorption of compounds with a Biopharmaceutics Classification System...

Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine

Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine

Publication: AAPS J
Software: GastroPlus®
Division: Simulations Plus

The purpose of this study was to develop simulation and modeling methods for the evaluation of pharmacokinetics when intestinal influx and efflux transporters are involved...

An investigation into the importance of “Very Rapid Dissolution” criteria for drug bioequivalence demonstration using gastrointestinal simulation technology

An investigation into the importance of “Very Rapid Dissolution” criteria for drug bioequivalence demonstration using gastrointestinal simulation technology

Publication: AAPS J
Software: GastroPlus®

The Biopharmaceutics Classification System (BCS) is based on the mechanistic assumptions that the rate and extent of oral drug absorption are governed by drug solubility...