The influence of the method of cimetidine administration on theophylline disposition was studied in nine healthy, cigarette smoking male volunteers. The treatment phases consisted of: A) theophylline...
Comparison of N-methylthiotetrazole dispositions in healthy volunteers following single intravenous doses of moxalactam, cefoperazone, and cefotetan
he N-methylthiotetrazole side chain (NMTT) that is present on several cephalosporins has been implicated in the development of antibiotic-associated hypoprothrombinemia.
Prospective Surveillance of Antibiotic-Associated Coagulopathy in 970 Patients
N-methyl-thio-tetrazole (NMTT) has been proposed as a causative factor in antibiotic-associated coagulopathy. To evaluate this hypothesis, a nationwide surveillance program was initiated to determine...
Inhibition of Enoxacin Absorption By Antacids or Ranitidine
Ten normal volunteers participated in a randomized, five-way crossover study to determine the effect of concurrent enoxacin and antacid or ranitidine administration on enoxacin absorption...
A Clinical Pharmacy-Oriented Drug Surveillance Network: Results of a Nationwide Antibiotic Utilization Review of Bacterial Pneumonia 1987
One hundred eighteen pharmacists enrolled in the Drug Surveillance Network completed a survey of antibiotic prescribing patterns for bacterial infections. A total of 319 hospitalized patients being...
The Population Pharmacokinetics of Theophylline in Neonates and Young Infants
The population pharmacokinetics of theophylline were evaluated using 391 theophylline serum concentration measurements from 108 neonates and young infants (postnatal age 0-26 weeks), who received...
Kinetics and Action of N-Methylthiotetrazole in Volunteers and Patients. Population-Based Clinical Comparisons of Antibiotics With and Without This Moiety
Normal volunteers and patients were studied to determine the relative importance of NMTT and patient risk factors in the production of hypoprothrombinemia. The normal volunteers demonstrated in vivo NMTT…
A Clinical Pharmacy-Oriented Drug Surveillance Network: II. Results of a Pilot Project
A nationwide network of clinical pharmacists has been organized for the purpose of collecting drug experience data generated during the routine clinical care of patients. In order to assess the utility...
A Clinical Pharmacy-Oriented Drug Surveillance Network: I. Program Description
The limitations of the new drug development process, particularly in regard to the evaluation of drug safety, have resulted in a need for monitoring drug experience in the postmarketing period. Although a...
An Evaluation of Population Pharmacokinetics in Therapeutic Trials. Part II. Detection of a Drug-Drug Interaction
The use of observational data, collected during the routine clinical care of patients, has been advocated as a means to obtain clinically relevant information regarding the pharmacokinetic parameters of...
Determinants of antibiotic-associated hypoprothrombinemia
Hypoprothrombinemia is a relatively uncommon event in the hospitalized patient. When it does occur, it often is associated with surgery, dietary vitamin K deficiency, renal dysfunction, malignancy, and broad-spectrum antibiotic therapy...
Inhibition of Theophylline Clearance by Coadministered Ofloxacin Without Alteration of Theophylline Effects
The influence of multiple doses of ofloxacin (ORF 18489) on the disposition of theophylline was studied in 15 male volunteers. Subjects were confined in the Clinical Research Unit for 13 days and given a...
An Evaluation of Population Pharmacokinetics in Therapeutic Trials. Part I. Comparison of Methodologies
NONMEM, a computer program that uses the method of extended least-squares analysis, has been advocated as a means of obtaining estimates of population pharmacokinetic parameters when only fragmentary...
Safety of a higher loading dose of phenobarbital in the term newborn
The conventional loading dose of phenobarbital for newborn infants with hypoxic-ischemic seizures, 20 mg/kg, often fails to control convulsive activity.
Neonatal Population Pharmacokinetics of Phenobarbital Derived from Routine Clinical Data
Routine clinical pharmacokinetic (PK) data collected from 59 preterm infants who received phenobarbital were analyzed to estimate population PK parameters. Birth weights ranged from 600 to 3,620 g...
A calculator program for clinical application of the Bayesian method of predicting plasma drug levels
A pharmacokinetic program that allows individualization of drug dosage regimens through the Bayesian method is described.
Population Pharmacokinetics of Procainamide from Routine Clinical Data
Routine clinical pharmacokinetic data collected from patients receiving procainamide were analysed to estimate population pharmacokinetic parameters. 116 plasma concentration determinations for procainamide...