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Feb 23, 2004

Simulation of Absorption, Metabolism, and Bioavailability

Summary

This chapter contains sections titled:

  • Introduction: Simulation Studies Relevant to Oral Absorption
  • Background
  • Use of Rule‐Based Computational Alerts in Early Discovery
  • Mechanistic Simulation (ACAT models) in Early Discovery
    • Automatic Scaling of k′a as a Function of Peff, pH, and log D
    • Mechanistic Correction for Active Transport and Efflux
  • Mechanistic Simulation of Bioavailability (Drug Development)
  • Conclusions

By Michael B Bolger & Robert Fraczkiewicz

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